Cannabis Rescheduling Explained: Schedule III Impact


The U.S. Capitol building in Washington, D.C., representing the federal administrative process for cannabis rescheduling.
Cannabis rescheduling requires formal rulemaking by federal agencies, including the Department of Justice and the Drug Enforcement Administration. (Photo: rickmcmillin / Depositphotos)

What does “cannabis rescheduling” mean?

Under the Controlled Substances Act, drugs are categorized into five schedules based on medical usefulness, abuse potential, and safety. Marijuana has been classified as a Schedule I substance since 1970 — alongside heroin and LSD. Schedule I substances are defined as having no accepted medical use and a high potential for abuse.

Rescheduling would move cannabis to Schedule III, a category that includes substances like ketamine and anabolic steroids. The change would formally recognize accepted medical use while keeping federal controls in place.

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President Donald Trump delivers remarks after signing an executive order to reclassify marijuana, directing federal agencies to expedite cannabis rescheduling from Schedule I to Schedule III.

Would rescheduling legalize marijuana?

No. Rescheduling would not legalize marijuana for recreational use, nor would it override state cannabis laws.

Cannabis would remain federally regulated, and state-legal markets would continue operating under existing frameworks. Criminal penalties related to trafficking and unlicensed activity would still apply.

Who has the authority to reschedule marijuana?

Only the federal government can reschedule a controlled substance, and the process is governed by administrative law.

The steps include:

  1. A medical and scientific review by the Department of Health and Human Services.
  2. A proposed rule issued by the Drug Enforcement Administration.
  3. A public comment period.
  4. Administrative hearings (if requested).
  5. A final rule published in the Federal Register.

An executive order can direct agencies to act faster, but it cannot unilaterally change cannabis’s legal status.

Why is Schedule III so important for cannabis businesses?

The most immediate impact would be the elimination of Internal Revenue Code Section 280E, which prevents businesses trafficking Schedule I or II substances from deducting ordinary operating expenses.

Removing 280E would allow cannabis operators to deduct rent, payroll, marketing, and other standard costs, dramatically improving cash flow and financial stability.

What would change — and what wouldn’t — under Schedule III?

Would change:

  • Federal recognition of accepted medical use.
  • Eligibility for standard business tax deductions.
  • Expanded medical and clinical research access.

Would not change:

  • Federal legalization.
  • State-by-state cannabis laws.
  • FDA approval requirements for cannabis-derived drugs.

How long could rescheduling take?

Even under expedited conditions, final rescheduling could take months, not weeks. Legal challenges, administrative delays, or congressional intervention could extend the timeline further.

Why this matters now

For the first time, all three branches of the federal process — the Department of Health and Human Services, the Department of Justice (which includes the DEA), and the White House — have publicly acknowledged cannabis’s medical value. Whether that alignment survives political and legal scrutiny remains the central question.

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President Donald Trump delivers remarks after signing an executive order to reclassify marijuana, directing federal agencies to expedite cannabis rescheduling from Schedule I to Schedule III.



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